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Siyaram Pandey

Siyaram Pandey       Dr. Siyaram Pandey
Biochemistry Ph.D. (J.N.U., New Delhi) spandey@uwindsor.ca
Professor
253-3000 Ext. 3701
277-1 Essex Hall
Personal Website   

Research Interests:

In the Pandey Lab, we have four major research areas of interest.

  • Oxidative Stress in Aging and Neurodegeneration.
  • Oxidative Stress in the Fibroblasts from Alzheimer’s Disease Patients.
  • Development of Single Domain Antibodies Against Pro-Apoptotic Proteins (Caspase-3 and Bax) to Block Cell Death Following Stroke.
  • Using Apoptosis Inducers as a Weapon Against Cancer.

For details please visit us at: http://uwindsor.ca/pandey.

Selected Publications:

62. Vshyvenko, Sergey; Scattolon, Jon; Hudlicky, Tomas; Romero, Anntherese; Kornienko, Alexander; Ma, Dennis; Tuffley, Ian; Pandey, Siyaram "Unnatural C-1 homologues of pancratistatin: Synthesis and promising biological activities"(2012).  Canadian J. Chem. 2012, 90,932-943.

61.  Pamela Ovadje, Caroline Hamm and Siyaram Pandey (2011) Efficient induction of extrinsic cell death by Dandelion Root Extract in human Chronic Myelomonocytic Leukemia (CMML) cells. PLoS ONE 7(2): e30604. doi:10.1371/journal.pone.0030604.

60. Dennis Ma, Phillip Tremblay, Manika Gupta, Ian Tuffley, Sabrina Ma, Sergey Vshyvenko, Tomas Hudlicky, and Siyaram Pandey (2011) Targeting Mitochondria & Oxidative Vulnerabilities with a Novel Synthetic Analogue of Pancratistatin in Combination with Piperlongumine for Cancer Therapy. Under Review for Molecular cancer Therapeutics (AACR Journal) MS# MS# MCT-11-0778

59.  Dennis Ma, Phillip Tremblay, Kevinjeet Mahngar, Jonathan Collins, Tomas Hudlicky, and Siyaram Pandey (2011). Selective Cytotoxicity Against Human Osteosarcoma Cells by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin is Potentiated by Curcumin. PLoS ONE  In Press.

58.  Pamela Ovadje1, Madona Chochkeh1, Pardis Akbari Asl1, Caroline Hamm2 and Siyaram Pandey (2012) Selective induction of apoptosis and autophagy through treatment with Dandelion Root Extractin human pancreatic cancer cells. PANCREAS, May 27, 2012 Epub ahead of print.  doi: 10.1097/MPA.0b013e31824b22a2

57. Ma D, Collins J, Hudlicky T, Pandey S. (2011) Enhancement of Apoptotic and Autophagic   Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast         Adenocarcinoma and Neuroblastoma Cells with Tamoxifen. Journal of Visualized        Experiments  In Press Accepted Aug. 2011.

56. Dennis Ma1, Phillip Tremblay1, Kevinjeet Mahngar1, Pardis Akbari-Asl1, Jonathan Collins2, Tomas Hudlicky2, and Siyaram Pandey (2011) Induction of Apoptosis and Autophagy in Human Pancreatic Cancer Cells by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin Submitted to  American J. Biomedical Sciences. In Pres.  July 2011.

55. Katie Facecchia, Lee-Anne Fochesato, Sidhartha D. Ray, Sidney J. Stohs and Siyaram Pandey (2011). Oxidative toxicity in neurodegenerative diseases:           role of mitochondrial dysfunction and therapeutic strategies. Journal of Toxicology. Published online 2011 July 14. doi:  10.1155/2011/683728

54. Dennis Ma,  Phillip Tremblay, Kevinjeet Mahngar, Pardis Akbari-Asl, Jonathan       Collins, Tomas Hudlicky, James McNulty, and Siyaram Pandey (2011) A Novel Synthetic C1 Analogue of 7-deoxypancratistatin Induces Apoptosis in p53 Positive and Negative Human Colorectal Cancer Cells by Targeting the Mitochondria: Enhancement of Activity by Tamoxifen. Investigational New Drugs. Published on line ahead of print, April 15, 2011 DOI 10.1007/s10637-011-9668-7.

53. Carly Griffin, James McNulty, Siyaram Pandey (2011) Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells. International J. Oncology, 2011;38(6):1549-56.

52. James McNulty, Amol Thorat, Nesrin Vurgun, Jerald J. Nair, Emilija Makaji,  Denis J. Crankshaw, Alison C. Holloway, Siyaram Pandey. (2011) Dihydronarciclasine: A Readily Available, Potent and Selective Cancer Cell Growth Inhibitor. J Nat Prod. 2011 Jan 28;74(1):106-8. Epub 2010 Nov 24. It is an American Chemical Society Journal.

51. Sudipa June Chatterjee and Siyaram Pandey (2011) Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy. Cancer Biology and Therapy2011 Jan 29;11(2) 216-228. [Epub ahead of print]PMID: 21088500.

50. Sudipa June Chatterjee, Pamela Ovadje, Caroline Hamm and Siyaram Pandey (2011) The Efficacy of Dandelion Root Extract in Inducing Apoptosis in Drug-resistant Human Melanoma Cells. In Press Evidence-based Complementary and Alternative Medicine (eCAM), doi:10.1155/2011/129045. Published online ahead of Print.

49. Carly Griffin, Aditya Karnik, James McNulty, Siyaram Pandey (2011) Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts. . Mol. Cancer Therapeutics. 10: 57-68. It is an American Association for Cancer Research Journal.

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